Association between antioxidant nutrients, depression, and cognitive function: The Mikkabi Active Aging Study

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K10617
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Nakamura Mieko 浜松医科大学, 医学部, 准教授 (30236012)
• Co-Investigator(Kenkyū-buntansha): 杉浦 実 同志社女子大学, 生活科学部, 教授 (10355406)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: カロテノイド / 高感度CRP / 炎症 / 野菜 / 日常生活動作

Outline of Final Research Achievements

A cohort study (The Mikkabi Study) was conducted from 2003 to 2013 to clarify the relationship between antioxidant carotenoids and lifestyle-related diseases. This study aimed to extend the follow-up period and the outcomes of the Mikkaibi Study to clarify the outcomes in older age. This study revealed sex differences in the association between applied activities of daily living scores (Frenchay Activities Index Japanese version, Hachisuka et al.) and self-rated health, S-WHO-5-J Japanese version; serum total carotenoids and green-yellow vegetable intake negatively associated with all-cause mortality, and serum lutein and zeaxanthin negatively associated with inflammation indices in nonsmokers.

Free Research Field

疫学

Academic Significance and Societal Importance of the Research Achievements

食事から摂取されるカロテノイドは生体内で酸化ストレスに防御的に働き、酸化ストレスを基盤とする疾患予防に有用と考えられる。しかし、日本食品標準成分表に一部のカロテノイドは収載されておらず、摂取量の評価は困難である。血清カロテノイドは摂取量を反映するが、これを評価するコホート研究は特に日本では少ない。本研究は三ケ日町研究を拡張することでカロテノイドの健康影響に関わる知見の創出に有用と考えられる。