Comparative study on arteriosclerotic index CAVI and urinary sodium-potassium ratio in different regions of Japan.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10652
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Keio University
• Principal Investigator: KUWABARA Kazuyo 慶應義塾大学, 医学部(信濃町), 助教 (70627637)
• Co-Investigator(Kenkyū-buntansha): 岡村 智教 慶應義塾大学, 医学部(信濃町), 教授 (00324567) ; 原田 成 慶應義塾大学, 医学部(信濃町), 講師 (10738090) ; 東山 綾 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20533003)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: CAVI / 尿中ナトリウム・カリウム比 / 動脈硬化性疾患 / 高血圧 / 危険因子 / 喫煙 / コホート

Outline of Final Research Achievements

Although the urinary Na/K ratio has been reported to be associated with cerebral and cardiovascular disease in patient populations, its association with the cardio-ankle vascular index (CAVI), a leading indicator of aortic arterial stiffness, has not been reported. It is also possible that differences in the contribution of the urinary Na/K ratio to arterial stiffness may be observed in populations with different lifestyles. Therefore, we compared and verified the association between CAVI and urinary Na/K ratio in the Kansai (Kobe Study) and Tohoku (Tsuruoka Metabolome Study) regions. The urinary Na/K ratio was significantly higher in the Tohoku region in both men and women, and the Na/K ratio tended to be higher in the group with high CAVI. The odds ratio was higher in the hypertensive/high urinary Na/K group.

Free Research Field

循環器疫学

Academic Significance and Societal Importance of the Research Achievements

異なる地域における動脈硬化の指標cardio-ankle vascular index ; CAVIと尿中ナトリウム・カリウム比（尿中Na/K比）に関する要因を検討することは、高血圧をはじめとした動脈硬化の進行に関わる要因を明らかにし、栄養介入による早期からの予防に繋がると考える。これらのことよりCAVIを一般住民や勤務者の健康管理に活用する可能性に加え、尿中ナトリウム・カリウム比を用いた保健指導に有用と考えられる。