Prevalence of HTLV-1 Infection and Associated Diseases in Goto-Islands' Population Based Cohort

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K10664
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Nagasaki University
• Principal Investigator: Nobusue Kenichi 長崎大学, 医歯薬学総合研究科(医学系), 研究協力員 (20823272)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 成人T細胞白血病ウイルス / ぶどう膜炎 / HTLV-1ぶどう膜炎

Outline of Final Research Achievements

Using data from a cohort study conducted by Nagasaki University in Goto City, Nagasaki Prefecture since 2014, we investigated the HTLV-1 infection rate and the prevalence of uveitis among HTLV-1-related diseases. Anti-HLTV-1 antibodies were tested in 4,265 people, approximately 12% of the total population, and 685 positive cases and 3,580 negative cases were confirmed. Next, we checked the medical records of four medical institutions with ophthalmology in Goto City, and found that 14 (2.0%) of the HTLV-1 positive patients and 18 (0.5%) of the negative patients had uveitis. Based on the above, logistic regression analysis showed that the odds ratio of developing uveitis in HTLV-1 positive patients was 4.13, and the odds ratio adjusted for age and sex was 3.27.

Free Research Field

疫学

Academic Significance and Societal Importance of the Research Achievements

このデータは、世界的にみてもHTLV-1感染率が高い地域において、住民を対象とした前向きコホート研究に基づきぶどう膜炎に対するHYLV-1感染の寄与率を明らかにした初のものである。本コホート研究は現在進行中であり、これを基礎に脊髄症など他のHTLV--1関連疾患ほ含む疾患への寄与率、あるいは脳卒中、心筋梗塞など、生活習慣病のへの寄与率の解明も期待される。
社会的には、HTLV-1感染率が高い地域においては、臨床医も患者自身も、HTLV-1感染者についてはぶどう膜炎の可能性を、ぶどう膜炎患者についてはHTLV-1感染の可能性を、常に念頭に置くべきであるとを示唆している。