Molecular mechanism of H2S donor on liver damage in an animal model of sepsis.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10680
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58040:Forensics medicine-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Unuma Kana 東京医科歯科大学, 大学院医歯学総合研究科, 准教授(キャリアアップ) (30586425)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 敗血症 / 硫化水素 / リポポリサッカリド / 敗血症性肝障害

Outline of Final Research Achievements

Hydrogen sulfide (H2S) has anti-inflammatory and anti-oxidant effects, and is known to have organ-protective effects in various inflammatory diseases. The purpose of this study is to demonstrate that hydrogen sulfide has a protective effect against acute liver damage caused by lipopolysaccharide (LPS) -induced sepsis. We revealed that the increase in cytokines in the septic group was alleviated by low concentrations of hydrogen sulfide. Furthermore, the gene expression level of peroxiredoxin 4 (Prx4) was increased in the septic group, and this increase tended to be suppressed by low concentrations of hydrogen sulfide. These results indicate that administration of hydrogen sulfide may help alleviate the pathological condition of sepsis.

Free Research Field

法医学

Academic Significance and Societal Importance of the Research Achievements

PRX4は細胞内では小胞体に多く存在する分泌型のタンパク質である。本研究の結果から、PRX4は敗血症病態を反映する可能性が示唆され、敗血症早期診断の有用なマーカーとなり得る可能性を明らかにした。また、敗血症病態への早期硫化水素投与により敗血症病態緩和に働く可能性が示された。これらの結果は、致死率の高い敗血症の早期診断、治療応用につながる可能性があり、学術的意義があるものと考える。