Changesl of peripheral serotonin by platelets in accordance to control of body temperature

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10691
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58040:Forensics medicine-related
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Nakamura Mami 滋賀医科大学, 医学部, 准教授 (70753763)
• Co-Investigator(Kenkyū-buntansha): 新谷 香 (石田香) 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (50345047)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: セロトニン / TRPV受容体 / 温感センサー / 薬剤性高体温 / 環境温度

Outline of Final Research Achievements

We previously reported that peripheral serotonin plays an important role in drug-induced hyperthermia under high ambient temperature using a 5-HT2A agonist 25B-NBOMe. In this study, we tried to clarify the role of TRPV receptors on the skin which sense the temperature. As a result, 25B-NBOMe related hyperthermia was not observed under TRPV4 receptor agonist stimulation, nor vice versa, suggesting that TRPV4 is not relevant to changes in peripheral serotonin levels according to ambient temperature.

Free Research Field

法医学

Academic Significance and Societal Importance of the Research Achievements

末梢セロトニンの変化とそれによる体温調節機構は、高体温を引き起こす様々な疾患の病態解明や治療に新しい視点を加えるものである。本研究で末梢セロトニン関連体温調節機構に対してTRPV4単独ではきっかけとなりえないことは、ポジティブな成果ではないものの、今後の同様の研究における重要な一歩であると考える。