2021 Fiscal Year Final Research Report

Discrimination and demonstration of parameters of finger motor dexterity for the diagnosis of dementia

Research Project

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Project/Area Number	19K11339
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 59010:Rehabilitation science-related
Research Institution	Fujita Health University (2021) National Center for Geriatrics and Gerontology (2019-2020)
Principal Investigator	Suzumura Shota 藤田医科大学, 保健衛生学部, 助教 (30790498)
Co-Investigator(Kenkyū-buntansha)	大沢愛子国立研究開発法人国立長寿医療研究センター, 病院, 医長 (10388944) 近藤和泉国立研究開発法人国立長寿医療研究センター, 病院, 副院長 (50215448)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	手指機能 / 認知症 / アルツハイマー病 / 手指巧緻性 / カットオフ / 軽度認知障害
Outline of Final Research Achievements	We examined whether dementia risk can be determined through finger movements. A total of 1097 subjects were assessed between 2013 and 2020, and finger taps were measured in 660 subjects in the dementia group and 437 subjects in the control group. A significant difference was seen, especially in the number of taps in the MCI group compared to the control group (p<0.001). A cut-off value of 30 taps was applied (sensitivity, 0.77; specificity, 0.67; AUC, 0.79). Significant differences were also observed in rhythm-related parameters. These parameters may be useful for capturing MCI risk. Finger taps are easily measured and may be suitable for screening large populations.
Free Research Field	Dementia
Academic Significance and Societal Importance of the Research Achievements	認知症と健常の中間である軽度認知障害（MCI）の時期から，歩行障害などの運動の障害を認めることが分かってきております．私たちは運動の障害を手指の運動（指タップ運動）から検出できるのではないか検討しました．結果，MCI患者では健康な高齢者と比較してタップ回数（親指と人差し指をタップする回数）が少なく、リズムが不安定となることがわかりました。今後はさらに研究を進め，認知症特有の手指運動巧緻性の低下が予測できれば、従来の診断法より早期に兆候をつかまえられる可能性があります。