Sarcopenia and frailty on the older cancer patients after treatments

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K11345
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Kobe University
• Principal Investigator: ONO Rei 神戸大学, 保健学研究科, 教授 (50346243)
• Co-Investigator(Kenkyū-buntansha): 牧浦 大祐 神戸大学, 医学部附属病院, 理学療法士 (40813944) ; 井上 順一朗 神戸大学, 医学部附属病院, 理学療法士 (50437472) ; 酒井 良忠 神戸大学, 医学研究科, 特命教授 (90397802)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 高齢がん / ロコモティブシンドローム / 健康寿命

Outline of Final Research Achievements

The purpose of this study was to examine whether or not cancer incidence in old age increase the incidence of need for support and care. Residents enrolled in National Health Insurance claims data, Latter-Stage Older Persons Health Care System claims data were included in the study. During the follow-up period, 16,088 persons developed cancer. In the Cox proportional hazard model adjusted for sex, age, Charlson Comorbidity Index, and medical expenses in the 6 months before diagnosis, the older in the incedence of cancer in the old ages were significantly higher care needs than that in no incidence of cancer selected by propensity score matching (HR 1.49; 95%CI 1.36-1.62).
The results suggested that the older with cancer are a desirable population for intervention in terms of care prevention, even after treatment.

Free Research Field

運動疫学

Academic Significance and Societal Importance of the Research Achievements

先進各国の高齢化に伴い、高齢期のがん罹患が増加し、それに伴い高齢がんサバイバーも増加している。
高齢がん患者における、がん治療成績向上に関する研究は散見されるが、高齢期のがん罹患が、健康寿命延伸に与える影響は明らかになっていなかった。
本研究により、高齢期のがん罹患は治療前後のみならず、治療後（退院後）も健康寿命延伸の観点から、積極的なリハビリテーションを展開する必要性があることを示唆できた。