2021 Fiscal Year Final Research Report
Influences of oxidative stress induced by high atmospheric pressure on noninsulin-dependent glucose metabolism in diabetes
Project/Area Number |
19K11346
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 59010:Rehabilitation science-related
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Research Institution | Hiroshima University |
Principal Investigator |
Fujita Naoto 広島大学, 医系科学研究科(保), 講師 (90584178)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 糖尿病 / 酸化ストレス / 高気圧 / 糖代謝 |
Outline of Final Research Achievements |
Hyperbaric normoxia treatment inhibited chronic inflammation in the white adipose tissue due to activated anti-inflammation in the skeletal muscle, which resulted in improvement of hyperglycemia and hyperinsulinemia in type 2 diabetes with obesity. However, the improvements were not found in chronic diabetes and high fat diet induced obesity, suggesting that the effectiveness of hyperbaric normoxia treatment depended on the pathology of metabolic related organs in diabetes. In the future, we have to investigate the influences of hyperbaric normoxia treatment on various situations.
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Free Research Field |
リハビリテーション科学
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Academic Significance and Societal Importance of the Research Achievements |
過食による肥満2型糖尿病の初期における高気圧処置の有効性を確認したこと、及び糖尿病の進行期や高脂肪食誘導性肥満の初期においてその有効性が減弱していたことは、高気圧処置の臨床応用を進める上で社会的意義があると考える。また、その作用機序には糖尿病に至る病理の関与が予想されることより、各種臓器における作用機序の確認、ならびに高気圧や高酸素の条件検討を行う必要性を見出したことが、学術的意義の一つであると考える。
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