Effects of respiration on central nervous system information processing

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K11350
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Toho University (2023); Aomori University of Health and Welfare (2019-2022)
• Principal Investigator: Ozaki Isamu 東邦大学, 医学部, 研究員 (90241463)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 呼吸リズム / 脳波 / コヒーレンス / 神経インパルス / 体性感覚

Outline of Final Research Achievements

We performed frequency analysis between respiratory rhythm and resting spontaneous EEG in normal subjects and found high coherence between respiratory rhythm and spontaneous EEG over a wide area on the scalp in subjects with stable respiratory rhythm. This is consistent with the results of animal experiments in rodents and with the results of human cortical EEG using deep electrodes, and is an important fact that the effects of respiratory rhythm on a wide range of brain activities, including somatosensory and frontal cortices as well as hippocampal activities can be recorded noninvasively over the scalp. In addition, we succeeded in visualizing the impulses propagating through the brachial plexus by neuromagnetic field and potential measurements, which is a continuation of our previous research.

Free Research Field

臨床神経生理学

Academic Significance and Societal Importance of the Research Achievements

本研究は，呼吸リズムが海馬活動のみならず体性感覚皮質や前頭葉皮質など広範囲の脳活動に周期的な影響を与えることを頭皮上から非侵襲的に記録できることを示した。また腕神経叢を伝播するインパルスの可視化において，磁界計測の結果から算出した神経外部の電位分布が実際の電位計測の結果と一致することを世界で初めて示したことは，今後の磁界計測の臨床への応用拡大の裏付けとなる知見であったと考えられる。