2022 Fiscal Year Final Research Report
Regulation of mitochondrial biogenesis in skeletal muscle
| Project/Area Number |
19K11433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | Fukushima University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 骨格筋 / ミトコンドリア / PGC-1α / 筋収縮 / 体液性因子 |
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| Outline of Final Research Achievements |
To elucidate the mechanism underlying the increase in skeletal muscle mitochondria, we investigated the effects of two factors: local factors such as muscle contraction activity and systemic factors such as sympathetic nerve activity. First, we injected norepinephrine into rats and measured sympathetic nerve activity and mitochondria-related proteins. The results showed that the increase in sympathetic nerve activity had no or extremely weak effect on mitochondrial increase in skeletal muscle. Furthermore, it was also revealed that propranolol did not inhibit the increase in mitochondria caused by exercise. Based on these results, it is considered that the contraction activity of skeletal muscle is important for the increase in skeletal muscle mitochondria, while the involvement of systemic factors is minimal.
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| Free Research Field |
運動生理学
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| Academic Significance and Societal Importance of the Research Achievements |
骨格筋のミトコンドリアの増加は持久性能力の向上や脂質代謝亢進を引き起こすため，骨格筋のミトコンドリアの増減メカニズムを明らかにすることは持久性競技種目におけるパフォーマンスの向上や代謝疾患の予防のために極めて重要である．先行研究では交感神経活動がミトコンドリアバイオジェネシスに重要な働きをしているという論文が発表されているが，本研究の成果はその成果と異なるものであった．本研究の結果は筋力の適応はトレーニングをした部位にのみ現れるというトレーニングの特異性の原理を裏付けるものであり，ミトコンドリアを増加させるためのトレーニング方法を考える上で重要な情報を提供している．
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