Seasonal and diurnal variations in exercise intensity thresholds in relation to changes in thrombosis-related factors

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K11444
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Nara Medical University
• Principal Investigator: Ishizashi Hiromichi 奈良県立医科大学, 医学部, 教育教授 (50260807)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: VWF / ADATS13 / 運動強度閾値 / 季節変動 / 日内変動

Outline of Final Research Achievements

In this study, we conducted running exercise at below the exercise intensity threshold (55% HRmax) during the summer and winter and during the morning and evening, and investigated the formation of blood clots before and after the exercise. By measuring thrombosis-related factors(VWF ,ADAMTS13), we examined whether the exercise intensity threshold at which thrombosis is thought to begin varies depending on season and time.
The results of the study revealed no statistical difference in the changes in thrombosis-related factors due to exercise in any season or in any time period. These results show that there is no change in thrombotic tendency during exercise below the exercise intensity threshold set here, indicating that it is not influenced by season or by time. However, in the case of the exercise enforcement, it was suggested that there was the need to be considered enough because a VWF/ADAMTS13 level showed high level before exercise with AM, PM in the winter season.

Free Research Field

スポーツ科学

Academic Significance and Societal Importance of the Research Achievements

スポーツ活動時には血小板、VWF、ADAMTS13（血栓形成関連因子）にバランスの崩れが生じ、「向」血栓性に傾くことが明らかにされている。その要因として、運動継続時間や発汗による脱水の程度よりも「運動強度」に影響され、VWFが著増することによって生じる運動強度閾値が50％VO2max付近にあることが明らかにされている。しかしながらこれらの結果は実験室的の快適環境で得られたものであり、日本のように四季の見られる地域では、「向」血栓化の閾値には季節や日内変動があり、注意を払う必要性が考えられる。