2022 Fiscal Year Final Research Report
Development of evaluation method for the three major nutrient utilization state during exercise using saliva sample
Project/Area Number |
19K11476
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 59020:Sports sciences-related
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Research Institution | Tokyo Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
本多 彰 東京医科大学, 医学部, 教授 (10468639)
池上 正 東京医科大学, 医学部, 教授 (40439740)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | エネルギー代謝 / 骨格筋 / 肝臓 / 分岐鎖アミノ酸 |
Outline of Final Research Achievements |
In endurance exercises and metabolic diseases, energy metabolism is altered. Based on the differences in energy metabolism between the liver and skeletal muscle, this study evaluated the influences of endurance exercise and branched-chain amino acids (BCAAs) ingestion on the metabolites of three macronutrients (carbohydrates, lipids, and amino acids) derived from the respective tissue in the saliva, which can be noninvasively collected. In the saliva, the metabolites were increased after the treadmill running, and also, the increase of the metabolite of muscular BCAA catabolism and the suppressions of the hepatic lipid metabolism and glycolysis by the BCAA ingestion could be evaluated in the saliva samples. Similar evidence was obtained in blood samples from the metabolic disease mouse model. From the results in saliva and blood, the changes in the energy metabolism balance between the liver and skeletal muscle could be visually observed using a wheel diagram.
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Free Research Field |
栄養エネルギー代謝
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Academic Significance and Societal Importance of the Research Achievements |
本研究では,非侵襲的に,自ら場所や時間,回数等に縛られる事なくサンプリングできる唾液を用いた。代謝の中心臓器である肝臓とエネルギー消費の中心臓器である骨格筋における三大栄養素由来のエネルギー代謝産物を高感度分析法にて測定し,臓器間の三大栄養素燃焼バランスを評価できた。そのため,運動選手のパフォーマンスやコンディショニングに加え,代謝性疾患患者の病態把握にも応用可能で,高齢者や子どもを含め幅広い層での活用が期待される。
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