The influence of short-term thiamin restriction and imbalance of energy substrate on energy metabolism at rest and in response to exercise

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11504
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Niigata University of Health and Welfare
• Principal Investigator: Sato Akiko 新潟医療福祉大学, 健康科学部, 准教授 (70593888)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: チアミン / ピルビン酸脱水素酵素複合体 / 間欠的高強度運動 / 低強度持久運動 / 高糖質食 / 高脂肪食

Outline of Final Research Achievements

The aim of this study was to investigate the influence of the short-term lowered level of cellular thiamin without symptoms associated with thiamin deficiency on the activity of pyruvate dehydrogenase complex (PDC) and on carbohydrate and fat metabolism by animal. The results indicated that lowered level of cellular thiamin did not change PDC activity at rest nor immediately after two types of exercise (high-intensity intermittent swimming and low-intensity swimming). In addition, this lowered cellular thiamin level did not affect the carbohydrate and fat metabolism even under the conditions of high-carbohydrate or high-fat diet.

Free Research Field

スポーツ栄養学

Academic Significance and Societal Importance of the Research Achievements

チアミン研究は歴史的に、長期の欠乏により生じる欠乏症の治療を目的として始まったが、現代ではそれほど長期のチアミン不足に陥ることは稀である。そのため体内チアミンの短期的な不足の影響は精査されてこなかったが、本研究により水溶性ビタミンであるチアミンも不足が短期であれば糖質および脂質代謝に影響を及ぼす可能性が低いことが示唆された。このことは盲目的なビタミン剤の摂取を抑制し、給食の現場における献立作成の自由度を増すことにもつながるものと考えられる。