Can genetic profile predict response to resistance training?

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11531
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Nippon Sport Science University
• Principal Investigator: Kikuchi Naoki 日本体育大学, 体育学部, 准教授 (10739478)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 筋力トレーニング / 遺伝子多型 / 筋力 / 筋肥大 / ゲノムワイド関連解析 / GWAS

Outline of Final Research Achievements

The purpose of this study was to discover novel genetic polymorphisms associated with individual differences in the effects of strength training in the general population using genome-wide association analysis(GWAS). In this study, 56 men and women participated in a total of 16 sessions of strength training, twice a week for 8 weeks.Strength, muscle mass, and muscle function were measured before and after the training period. This study identified 95, 17, and 27 novel genetic polymorphisms associated with isometric knee extension muscle strength, thigh muscle cross-sectional area, and rate of change in the 30-second chair stand test, respectively, by GWAS. Further investigation of these polymorphisms is needed in the future.

Free Research Field

トレーニング科学

Academic Significance and Societal Importance of the Research Achievements

本研究では、筋力トレーニングの効果に影響する遺伝子多型の検出を目指した。筋力トレーニングによる筋機能や筋量の上昇に対してトレーニング効果の個人差がある。遺伝子多型によってスクリーニングすることによって、個人対応型のトレーニングプログラムが期待できる。さらに、血圧上昇に対するリスクやサプリメント摂取による効果の違いなど、さまざまな個人差を把握することができる。