Investigating the levels of school club activities based on DNA damage and recovery capacity in adolescent girls

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11617
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59030:Physical education, and physical and health education-related
• Research Institution: Okayama Healthcare Professional University (2020-2021); The University of Tokyo (2019)
• Principal Investigator: Yasuda Nobuo 岡山医療専門職大学, 健康科学部 作業療法学科, 教授 (00467119)
• Co-Investigator(Kenkyū-buntansha): 谷岡 利裕 昭和大学, 薬学部, 准教授 (80360585) ; 中澤 公孝 東京大学, 大学院総合文化研究科, 教授 (90360677)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 酸化ストレス / DNA損傷・修復能 / 酸素摂取能力 / ステロイドホルモン / 第二次急伸期 / ミトコンドリアDNA

Outline of Final Research Achievements

The purpose of this study was to examine DNA damage and repair capacity after moderately prolonged exercise in relation to estrogen concentration, cardiorespiratory endurance (ventilatory threshold and peak oxygen uptake), and mitochondrial DNA copy number in adolescent female middle and high school students (14-18 years old, just after the second rapid growth phase) engaged in sports-related club activities. Whole body DNA damage and repair capacity as indicated by urinary 8-OHdG levels (8-OHdG, ng/mg creatinine) showed no significant correlation with urinary estrogen concentration, cardiopulmonary endurance, or salivary mitochondrial DNA copy number. These results suggest that DNA damage and repair exerted by transient moderate-intensity endurance exercise is not significantly affected by changes in estrogen concentrations associated with the follicular and luteal phases in physically active adolescent girls.

Free Research Field

複合領域

Academic Significance and Societal Importance of the Research Achievements

成長期女子のDNA損傷・修復能と心肺持久力、ミトコンドリアDNAコピー数及びエストロゲン濃度に関する作用機序については未知な部分が多い。その点で、本研究で得られたデータから、性周期による身体コンディションの状態をチェックし、パフォーマンスの維持・向上を目指した部活動実施基準を設定する上で重要な手掛かりとなり、有益性の高い情報を学校体育現場にフィードバックする一助となった。