2021 Fiscal Year Final Research Report
Dietary and nutritional approaches for prevention of type 2 diabetes targeting lipoprotein receptor and selenoprotein P
| Project/Area Number |
19K11646
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Osaka City University |
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Principal Investigator |
KIM DongHo 大阪市立大学, 大学院生活科学研究科, 准教授 (70326271)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | リポタンパク質受容体 |
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| Outline of Final Research Achievements |
Abundance selenoprotein P induces insulin resistance and causes the onset of type 2 diabetes. The wnt signal transduction is involved in the insulin secretion mechanism. In this study, we investigated the expression pattern of lipoprotein receptor family genes that function as receptors for selenoprotein P and wnt. We also investigated the effects of lipoprotein receptor family genes on wnt signaling activity and selenoprotein P expression.
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| Free Research Field |
生体機能学
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| Academic Significance and Societal Importance of the Research Achievements |
私たちはこれまでに複数のリポタンパク質受容体遺伝子を発見しその機能について明らかにしてきた．本研究では，リポタンパク質受容体遺伝子の新たな機能であるwntとセレノプロテインPの受容体としての役割を担う可能性について検討行い，apoer2以外にLRP10の関与を示唆するデータが得られた．今後，インスリンシグナルに対するLRP10の影響を調べる必要があると考える．
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