Elucidation of the molecular basis of the interaction of lipid intake on the kinetics of mineral absorption and metabolism and practical research

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11670
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: University of Shizuoka
• Principal Investigator: ARAI HIDEKAZU 静岡県立大学, 食品栄養科学部, 教授 (60325256)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ミネラル代謝 / マグネシウム / カルシウム / リン / 腎臓 / 消化吸収

Outline of Final Research Achievements

The objective of this study was to evaluate the metabolic response of the body to a combination of major and micronutrients, and to determine whether a 24-hour urine storage method can be used to assess mineral nutritional status. In animal studies, high-fat diets decreased intestinal calcium absorption, and increased magnesium and phosphorus absorption compared to high-carbohydrate diets, and affected the absorption and metabolism of minerals. In addition, we evaluated the mineral balance in healthy women after a prescribed diet for a certain period of time using the 24-hour urine storage method, and found that it is possible to evaluate the mineral balance as an estimate.

Free Research Field

臨床栄養学

Academic Significance and Societal Importance of the Research Achievements

「食事」は複数の栄養素を同時に摂取するため、特定の栄養素が生体に及ぼす影響を評価するには、他の栄養を同時摂取した際の複合的な評価が必要である。リンをはじめとしたミネラル管理が重要である慢性腎臓病患者のみならず、栄養不良を伴う高齢者に対しても、適切な栄養療法（主要な栄養素および微量栄養素の組み合わせ）を通じて栄養管理しなければならない。したがって、本研究は疾病の改善や増悪予防を目指した実践臨床栄養学領域の研究である。