ABC transporters-based analysis for the mechanism of growth and aging in the musculoskeletal system

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11678
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Chubu University
• Principal Investigator: Nakagawa Hiroshi 中部大学, 応用生物学部, 准教授 (40397039)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ABC輸送体 / 骨 / 筋肉 / 脂肪

Outline of Final Research Achievements

We evaluated the effects of each gene on bone, muscle, and fat in three strains of mice that are independently deficient in the Abca1, Abcb4, and Abcc5 genes.
We found that Abca1- and Abcc5-deficient mice had significantly shorter bone lengths than wild-type mice. We also found that the weights of fat and muscle of Abca1- and Abcc5-deficient mice were significantly lower than those of wild-type mice. On the other hand, we found no effects of Abcb4 gene deletion in bone, muscle, or fat.

Free Research Field

ABC輸送体学、細胞工学

Academic Significance and Societal Importance of the Research Achievements

本研究では、「ABC輸送体は、運動器の成長/機能を体内で調節している」という独自の仮説に基づいた研究を進展させ、「運動器の成長/老化」・「ABC輸送体」・「栄養/シグナル伝達因子」の連関を分子レベルで理解することを目指している。
本研究の完成は、「発育不良」や「運動器障害」を導く分子機構の熟知に加え、「発育不良」や「要支援・要介護・寝たきり」の個人差予測、食事・栄養補助療法の考案へと我々を導く。したがって、本申請課題は、「橋渡し研究」への発展を左右する基礎研究としても大きな価値がある。