A proposed novel method for screening caloric restriction mimetics and its application

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11707
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Matsuyama University
• Principal Investigator: Nakajima Mitsunari 松山大学, 薬学部, 教授 (70311404)
• Co-Investigator(Kenkyū-buntansha): 奥山 聡 松山大学, 薬学部, 准教授 (40550380) ; 天倉 吉章 松山大学, 薬学部, 教授 (50321857)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: カロリー制限模倣物 / 健康寿命延伸物質 / SIRT1

Outline of Final Research Achievements

Caloric restriction (CR) is a major contributor to good health and longevity. CR mimetics (CRMs) are a group of compounds capable of inducing the benefits of CR. In the present study, we propose the application of a T-cell activation-inhibitory assay to screen candidate CRMs. Using this assay, we found three candidate CRMs (Heptamethoxyflavone, Cynandione A and Ibudilast) that have beneficial functions for health such as anti-inflammatory effect. These results suggest that the T-cell activation-inhibitory assay can be used to screen candidate CRMs.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

ヒトにおいてカロリー制限が寿命を延伸させるか否かについては未だ結論は出ていないが、適度にカロリーを制限することは健康寿命を延伸させる方向に作用することが推察され、研究者の注目を集めている。こうしたことから、カロリー制限による苦痛を感じることなく、健康寿命延伸のメカニズムを促進させる物質（カロリー制限模倣物）の探索が望まれている。