Elucidation of gender differences in the pathogenesis of diabetic angiopathy focusing on vascular endothelial function and its application to gender-specific medicine

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kawasaki Medical School
• Principal Investigator: Takenouchi Yasuhiro 川崎医科大学, 医学部, 助教 (30582233)
• Co-Investigator(Kenkyū-buntansha): 岡本 安雄 川崎医科大学, 医学部, 教授 (80293877) ; 坪井 一人 川崎医科大学, 医学部, 准教授 (80346642)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 糖尿病 / 血管機能 / 性差

Outline of Final Research Achievements

It is known that the risk of vascular disorders such as atherosclerosis is lower in women than in men, but this is reversed when diabetes mellitus is concurrently present, and is reported to be higher in women than in men. In this study, we aimed to elucidate the differences in vascular function by gender using a mouse model of diabetes mellitus. The results showed that female diabetic models do not develop vascular endothelial dysfunction, but do develop atherosclerosis. One factor was thought to be altered expression of lysophosphatidic acid receptors.

Free Research Field

薬理学

Academic Significance and Societal Importance of the Research Achievements

未だ詳細に解明されていない糖尿病による血管合併症のメカニズムについての性差に着目した検討は、これまでほとんど行われていない。本研究により検出された性別による血管機能や遺伝子発現変化は、性別に適合した医薬品や候補化合物を見出し、新たな性差医療への治療方策が提示できるものと期待される。本研究は、糖尿病患者における合併症の発症抑制や軽減へとつながり、学術的のみならず患者への貢献は大きく意義深いものである。