2022 Fiscal Year Final Research Report
Development of a Nutritional Test for Patients with Liver Cirrhosis Using Metabolome Analysis
Project/Area Number |
19K11742
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 59040:Nutrition science and health science-related
|
Research Institution | Doshisha Women's College of Liberal Arts (2022) The University of Tokushima (2019-2021) |
Principal Investigator |
Okumura Hisami 同志社女子大学, 生活科学部, 准教授 (30322259)
|
Project Period (FY) |
2019-04-01 – 2023-03-31
|
Keywords | 臨床栄養 / メタボロミクス / 栄養検査 / 肝疾患 |
Outline of Final Research Achievements |
I have been working for many years on the development of nutritional therapy for patients with cirrhosis. Branched-chain amino acids (BCAAs) are effective nutrients in the nutritional management of patients with cirrhosis. However, there are very few reports on the timing and amount of their administration. Recently, metabolomics has made it possible to measure metabolites that previously could not be assessed; the ultimate outcome of successful utilization of BCAAs in the body is muscle gain, but many factors can be assumed, including the need for long-term observation. Therefore, it would be a highly accurate nutritional therapy if the nutritional status could be assessed in a short period of time and the diet could be modified as soon as possible. Therefore, we evaluated whether BCAAs were successfully utilized in the short term by assessing intermediate catabolic metabolites of BCAAs.
|
Free Research Field |
臨床栄養
|
Academic Significance and Societal Importance of the Research Achievements |
メタボロミクスは、代謝物を測定することで、詳細な代謝の変化を可視化できる技術であり、生体試料中の代謝物から、表現型の変化を明らかにすることができる。 このように、血清を組織の代謝物を測定し、腫瘍組織と非腫瘍組織の代謝物を抽出することで、腫瘍に特徴的な代謝物が抽出することは、今後、栄養療法や治療のためにより詳細な解析を行うための基礎的な研究となることが期待できる。
|