Preventive Effect of Subaleurone Layer Persistence Milled Rice and Dewaxed Brown Rice on Pollinosis : Human Intervention Study.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11745
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: The University of Nagano
• Principal Investigator: UENOBE MAYA 長野県立大学, 健康発達学部, 講師 (00413576)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 花粉症 / ロウ層除去玄米 / QOL / 自然免疫

Outline of Final Research Achievements

Dewaxed brown rice (DBR) is prepared by removing the outermost wax layer of brown rice. We have reported that DBR activates innate immune system macrophages and alleviates seasonal allergic rhinitis symptoms in mice. However, the effect on seasonal allergic rhinitis in humans has not yet been investigated. Therefore, we examined the effect DBR consumption on seasonal allergic rhinitis symptoms in volunteers. In a parallel-group comparison trial, 28 participants who have experienced seasonal allergic rhinitis symptoms in the past 2 years during the pollen season were divided into 2 groups. Participants consumed either white rice (WR) or DBR for 5 months. Once a week during the trial, participants recorded symptoms using the Japan Rhinitis Quality of Life Questionnaire No.1 (JRQLQ No.1). Medication use was recorded daily. Analysis of JRQLQ No. 1 and medication use suggests that individuals with seasonal allergic rhinitis may be able to manage symptoms by consuming DBR.

Free Research Field

栄養学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、増加傾向にある花粉症有症者の重大な健康問題であるQOLの改善、ひいては、花粉症予防に貢献できる。本研究は、新精米技術によって作成された精白米と玄米の長期間の継続摂取が、花粉症予防や症状改善に及ぼす効果を検証するために実施するヒトを対象とした初めての研究である。