Development of a psycho-physiological model of irritable bowel syndrome using adrenal hormones in nail samples

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K11771
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Yokohama City University
• Principal Investigator: SUGAYA Nagisa 横浜市立大学, 医学部, 助教 (90508425)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 過敏性腸症候群 / 副腎皮質ホルモン / 爪 / ストレス / 認知 / 行動

Outline of Final Research Achievements

The purpose of this study was to investigate the relationship between adrenal hormones in nail samples and irritable bowel syndrome (IBS)-specific cognitive and behavioral factors. Although we were ready to conduct the study, the high frequency of alcohol disinfection and other factors due to the COVID-19 pandemic could have affected the results. As a result, it was impossible to start the data collection while waiting for the pandemic to subside and life to normalize. Therefore, during the study period, we have been preparing to proceed with this research plan more effectively by examining the results of the analysis using existing nail samples for this study and validating the cognitive and behavioral assessment scales to be used more precisely.

Free Research Field

心身医学

Academic Significance and Societal Importance of the Research Achievements

IBSに特化した認知・行動指標は心理的介入において重要な変数であり、これらがどのような生理的変化や症状と関連するかを検討することはIBSの病態理解とより効果的な介入方法の構築に大きく貢献することが期待できる。また、IBSは慢性疾患であるため、これまでのIBS研究で非侵襲的な試料として測定に用いられてきた唾液よりも、長期的な分泌を反映する爪（または毛髪）試料の方がIBSの病態との関連を検討する上ではより適している。研究期間中はCOVID-19パンデミックのためにこれらの新しい試みの準備に留まったが、IBS研究やストレスバイオマーカーの発展に役立つ成果を発信できたと考える。