2022 Fiscal Year Final Research Report

Analysis of the effect of traditional health methods on improving respiratory function using bioimaging

Research Project

PDF

Project/Area Number	19K11789
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	Tokyo University of Agriculture and Technology
Principal Investigator	Fujita Eri 東京農工大学, 工学(系)研究科(研究院), 研究員 (50466877)
Co-Investigator(Kenkyū-buntansha)	清水美穂東京農工大学, 工学(系)研究科(研究院), 客員准教授 (00500399) 平工志穂東京女子大学, 現代教養学部, 教授 (30302821) 田中幸夫東京農工大学, 工学(系)研究科(研究院), 名誉教授 (60179794) 跡見順子東京農工大学, 工学(系)研究科(研究院), 客員教授 (90125972)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	卵殻膜 / 細胞外マトリクス / 肺線維症
Outline of Final Research Achievements	In a human study, respiratory function was significantly increased in the group that ingested eggshell membrane compared to the control group. Radiolabeled eggshell membrane was also orally administered to mice to clarify the pharmacokinetics of eggshell membrane. Image analysis and gene expression analysis of mouse lung tissue and lung fibroblasts revealed that eggshell membrane significantly increased the expression level and secretion of decorin, which is known to prevent fibrosis and maintain healthy collagen fiber formation. Oral administration of eggshell membrane to mice models of pulmonary fibrosis significantly increased the level of decorin in the alveoli and reduced TAZ nuclear migration, a marker of pulmonary fibrosis. These results suggest that eggshell membrane improves the extracellular environment of lung tissue, thereby reducing pulmonary fibrosis and improving respiratory function.
Free Research Field	生命科学
Academic Significance and Societal Importance of the Research Achievements	高齢化に伴い呼吸器疾患は増加しており、特に肺線維症については根本的な治療法がない。肺線維症の緩和を目指し、入手が容易で伝統的に創傷治癒効果があるとされてきたニワトリ卵殻膜に注目した。我々は天然素材・卵殻膜が、弾力性に富む細胞外マトリクス成分であるデコリンやIII型コラーゲンの発現を誘導するという作用機序を利用し、呼吸機能改善や肺線維症にも有効なアプローチを開発した。卵殻膜の経口摂取は、肺組織の細胞外環境を改善することにより肺の健康に寄与する栄養/機能性食品として期待できる。