2023 Fiscal Year Final Research Report
Effects of diet and exercise on renal fibrosis in chronic kidney disease model rats
Project/Area Number |
19K11795
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 59040:Nutrition science and health science-related
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Research Institution | Prefectural University of Kumamoto (2021-2023) University of Shizuoka (2019-2020) |
Principal Investigator |
Yoshida Takuya 熊本県立大学, 環境共生学部, 准教授 (80622448)
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Project Period (FY) |
2019-04-01 – 2024-03-31
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Keywords | 腎臓 / 脂質 / 代謝 / 運動 |
Outline of Final Research Achievements |
In chronic kidney disease, abnormalities in energy metabolism are observed in the kidneys, and it may relate to the progression of renal damage. Furthermore, progression of renal damage induces skeletal muscle atrophy, which contributes to sarcopenia. In this study, we investigated the effects of diet and exercise on renal fibrosis and skeletal muscle mass and quality using chronic kidney disease model rats. The results showed that exercise had a renal protective effect in the rats fed a high-fat diet. In addition, lowering the fat content in the diet inhibited the progression of renal damage, similar to the effect of exercise. The combination of diet and exercise was suggested to affect the quality, rather than the skeletal muscle mass.
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Free Research Field |
臨床栄養学
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Academic Significance and Societal Importance of the Research Achievements |
近年、世界的に慢性腎臓病患者数が増加している。慢性腎臓病の食事療法や運動療法については、科学的根拠が少ないため、誤った食事療法や運動制限が行われたりしている。本研究により、食事と運動療法を組み合わせて腎障害の進展を抑制することが慢性腎臓病によるサルコペニアにも有用である可能性が示唆された。今後、さらに詳細に適切なエネルギー産生栄養素の摂取比率や運動による効果が明らかとなれば、食事療法や運動療法による慢性腎臓病の予防や重症化予防の重要性が明らかとなり、患者の健康寿命の増進、QOLの改善、医療費の削減などに貢献できる可能性があるため、本研究成果は社会的意義があると考える。
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