2022 Fiscal Year Final Research Report
A neural circuit controlling experience-dependent auditory preference behavior: Identification of relevant brain regions and its dynamics analysis
| Project/Area Number |
19K12190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 61060:Kansei informatics-related
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| Research Institution | Meiji University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
冨永 貴志 徳島文理大学, 神経科学研究所, 教授 (20344046)
高島 一郎 国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 上級主任研究員 (90357351)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 聴覚 / 嗜好性 / 選択行動 / 嗅周囲野 / 膜電位イメージング |
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| Outline of Final Research Achievements |
The present study addresses whether our feelings of preference are formed by past experiences (memories) or innate. We investigated this issue by focusing on the auditory system of rats. First, we divided sound sources into two groups, the "reward-related" and the "reward-unrelated" groups, and presented them to the rats in a two-choice maze. The results showed that 1) the rats avoided the white noise used for comparison with the other sound stimuli even after the reward acquisition experience. However, 2) the sound stimulus with tone and melody was preferentially selected after the reward-acquisition experience. In addition, membrane potential imaging in ex vivo brain slices showed that the perirhinal cortex, which is thought to be involved in the familiarity evaluation of input information, is under the control of a robust inhibitory system, which may complicate the in vivo pharmacological analysis of the above results.
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| Free Research Field |
神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
嗜好性・審美性にかかわる神経基盤については，既にヒトを対象とした研究で一定の知見が蓄積されるまでに至っている．その一方で，過去の体験に応じて嗜好に関する評価が変動するのか，という記憶処理との関連性を念頭においた調査は，十分に進んでいるとは言えない．本研究は，ラットの聴覚嗜好性行動を，生得的要因と後天的な要因を区別して調査する試みであり，得られた知見は，なぜ，我々が普段聞く曲に好き嫌いがあるのか，といった聴覚系嗜好性の問題にとどまらず，我々が好む音楽が人により異なるのは，生活環境での体験の違いによるものなのか？といった学習・記憶に依存した嗜好性の問題を解く手がかりを与える．
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