2021 Fiscal Year Final Research Report
The effect of acetylcholine on leaning function in CA3 in the hippocampus
Project/Area Number |
19K12223
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 62010:Life, health and medical informatics-related
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Research Institution | Tamagawa University |
Principal Investigator |
SUGISAKI Eriko 玉川大学, 脳科学研究所, 研究員 (20714059)
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Co-Investigator(Kenkyū-buntansha) |
相原 威 玉川大学, 工学部, 教授 (70192838)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 海馬 / CA3 / アセチルコリン / STDP |
Outline of Final Research Achievements |
Two types of pyramidal neurons, thorny and athorny cells, are existed in CA3 area of the hippocampus. Thorny cell has an input from dentate gyrus, while recently discovered athorny cell has an input from and output to thorny cells in the local area. Spike timing-dependent plasticity (STDP) was observed in both cells, and the magnitude of STDP was larger in thorny cell if acetylcholine (ACh) was applied. However, smaller STDP with ACh treatment was observed in athorny cell at a specific spike timing of STDP protocol. These results indicate that ACh is an important neuromodulator controlling thorny and athorny cells to function "learning" and "memory retrieval".
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Free Research Field |
神経科学
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Academic Significance and Societal Importance of the Research Achievements |
本研究では、近年発見されたathorny細胞に注目して学習時のCA3ネットワーク変化をSTDPを通して明らかにし、さらに集中・注意が働くとathorny細胞ではthorny細胞のような結合強化が見られないことが分かった。この新しい学習機能を人工知能に実装できると、限られた資源の中で情報処理能力を高める現在よりも効率的な人工知能の構築に寄与できることが期待できる。その結果、今までよりも高速処理が可能で精緻な機器の開発に役立てることができると考える。
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