2021 Fiscal Year Final Research Report
Transmission and infection mechanism of drug-resistant bacteria in aquatic environments
Project/Area Number |
19K12357
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 63040:Environmental impact assessment-related
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Research Institution | Yamaguchi University |
Principal Investigator |
KOBAYASHI Yuki 山口大学, 大学院医学系研究科, 准教授 (80759457)
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Co-Investigator(Kenkyū-buntansha) |
松井 一彰 近畿大学, 理工学部, 教授 (40435532)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 薬剤耐性菌 / ワンヘルス / 自然河川 / 腸内細菌 |
Outline of Final Research Achievements |
Inappropriate use of antibiotics gave rise to increasing cases of infections caused by drug-resistant and/or multi-drug resistant bacteria in recent years, thus making it a major social problem. Although it is already known that multi-drug resistant bacteria and its genes can be detected in the hospital or in human body, there are a still wide gap in our understanding of their dynamics in the natural environment. In this study our objective is to investigate their environmental presence using sequencing analysis and homology studies. Our results show that multidrug-resistant bacteria were present in all the collected water samples and with the genus Pseudomonas(26.7%), Serratia(20.0%), and Ochrobactrum (20.0%)representing the major populations. These results suggest that there are more multi-drug-resistant bacteria in the water environment including of ESBL producer/s.
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Free Research Field |
環境微生物
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Academic Significance and Societal Importance of the Research Achievements |
2016年に厚生労働省により,WHOの「薬剤耐性に関する国際行動計画」アクションプランが制定された.これは,ヒトの健康を守るためには,人間だけでなく動物や環境も考慮しながら対策を行う必要があるという概念である「ワンヘルス・アプローチ」の視点から作成されたものである.今や薬剤耐性菌問題は人だけに着目するのではなく,動物や環境にも目を向けた対策を取る必要に迫られている.水環境中では,畜産農場や水産養殖場処理水や病院排水などで,多くの薬剤耐性菌が存在するといわれており,本研究ではグラム陰性桿菌を対象とした多剤耐性菌を検出した.この結果は環境における耐性菌対策を取る上で非常に重要な結果である.
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