2021 Fiscal Year Final Research Report
A study on mechanism of mild traumatic brain injury
| Project/Area Number |
19K12782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 軽微な脳損傷 / 脳脊髄液漏出症 / 脊髄硬膜 / 二軸引張 / コンタクトスポーツ |
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| Outline of Final Research Achievements |
The dura mater is the thick and outermost layer and is the strongest membrane among the spinal meninges. Thus, mechanical failure of the dura mater can lead to spontaneous cerebrospinal fluid leaks or hypovolemia, resulting in a complication or exacerbation of unfavorable symptoms involved in a mild traumatic brain injury. In this study, we employed a custom equiload biaxial tensile tester to investigate the mechanical properties of porcine meningeal dura mater along the whole length of the spine. The resultant strain of the dorsal side was greater than that of the ventral side (P < 0.01), while the circumferential direction was significantly stiffer than the longitudinal direction (P < 0.01) at lower strains regardless of the spinal level. Further, Young’s modulus was significantly less on the dorsal side than on the ventral side at higher strains (P < 0.05), suggesting that the dorsal side is readily elongated by spinal flexion even within the range of physiological motion.
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| Free Research Field |
傷害バイオメカニクス
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| Academic Significance and Societal Importance of the Research Achievements |
脳脊髄液漏出症の受傷メカニズムは解明されておらず，有効な対策や効果的な治療法は未だ確立されていない．そのため，脳脊髄液漏出症の予防には依然として多くの課題が残されているのが現状である．しかしながら，人体有限要素モデルを活用し，現実の事故を忠実に模擬した衝突解析を実行することができれば，今まで原因不明とされてきた脊髄硬膜の損傷メカニズムを解明する糸口を掴めるのではないかと期待される．本研究で得られた成果は数値解析に直接応用可能であり，近い将来，脳脊髄液漏出症の受傷メカニズム解明に大いに寄与するものと考えられる．
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