2021 Fiscal Year Final Research Report
Quality assurance method for the accumulation of radiotherapy dose with deformable image registration
| Project/Area Number |
19K12818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90130:Medical systems-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
林 直樹 藤田医科大学, 保健学研究科, 准教授 (00549884)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ゲル線量計 / 変形画像照合 / 合算線量 / 放射線治療 |
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| Outline of Final Research Achievements |
In this study, we challenged to develop a method for verifying the accuracy of the accumulated dose distribution calculated with the deformable image registration (DIR) in radiotherapy. We use a gel dosimeter that can be measured three-dimensionally and can be deformed. We irradiated the gel dosimeter before and after the deformation, also scanned it by CT scanner and build each treatment plan, then the accu,ulated dose distribution by DIR was calculated. The accumulated dose distribution was compared with the dose distribution read from the gel dosimeter. Since the sensitivity of the gel dosimeter decreases when gel dosimeter is exposed to oxygen, an oxygen blocking method for the verification method could be developed. And it was found that the gelatin of the gel dosimeter collapsed due to the deformation of the gel dosimeter and the sensitivity of the collapsed part decreased.
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| Free Research Field |
放射線治療技術
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| Academic Significance and Societal Importance of the Research Achievements |
ゲル線量計による放射線治療の線量合算の評価はチャレンジングな部分が多くある.今回用いたゲル線量計の1つであるポリマーゲル線量計には酸素によって感度を失うことも克服する必要があり, ゲル線量計の封入袋, それによる酸素透過の遮断方法を開発できた. しかし,ポリマーゲル線量計はゲルの形状を保っているゼラチンが崩壊することで,単に形の違いだけではなく感度も異なってくることが分かったことは重要な結果である.
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