2021 Fiscal Year Final Research Report
Treatment planning method based on computational simulation of photodynamic treatment
| Project/Area Number |
19K12822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90130:Medical systems-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 光線力学治療 / PDT / 術前治療計画 |
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| Outline of Final Research Achievements |
Photodynamic therapy (PDT) is a low-invasive cancer treatment by laser irradiation of photosensitizers. Talaporfin sodium-mediated PDT is an operation for primary malignant brain tumors and done for a radical cure of the remaining tumors after surgical removal of the primary central tumor. Photodynamic therapy PDT by talaporfin sodium uses anti-tumor effects triggered by laser irradiation. The laser irradiation positions need to be designed according to light propagation in the tissue region of interest. This study presented a simulated annealing-based method to optimize laser irradiations position by quantitative comparison of light propagation. The numerical results confirm that laser irradiation positions and angles at which maximum laser irradiation ranges in treatment regions and avoid over-irradiation.
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| Free Research Field |
レーザー医学
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| Academic Significance and Societal Importance of the Research Achievements |
標的対象へ光感受性薬剤を選択的に集積させ，光照射により治療する光線力学治療（PDT）では，低侵襲で有効的なガン治療が可能である．現在までに多くの臓器の悪性腫瘍に対する臨床応用が示されているだけでなく，我が国においてはこれまでに早期肺がん，早期食道がん，胃がん，早期子宮頚がん，原発性悪性脳腫瘍に対するPDTが保険適応されており，良好な成績が示されている．本研究成果は，PDTにおける光照射条件を決めるための治療計画手法を提供するものであり，PDTのより安全で効果的な実施や迅速な適用範囲の拡大につながると期待できる．
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