Evaluation and minimization of Biometal as an exothermic material for cancer ablation therapy and its application for ablation instruments

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K12831
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Ritsumeikan University
• Principal Investigator: Nakamura Naotake 立命館大学, 総合科学技術研究機構, 上席研究員 (10066722)
• Co-Investigator(Kenkyū-buntansha): 新田 哲久 滋賀医科大学, 医学部, 非常勤講師 (40324587)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 5フレンチ / 導電性接着剤 / BMX / 焼灼

Outline of Final Research Achievements

This study is to provide a low-invasive and inexpensive instrument for treatment of cancer, which is said to affect one in two people in recent years. For this study, we selected thermal therapy which has been known and proven effective for a long time. For a tumor, an ablation at 60℃ for about 10 min. is expected to be effective.
We focused on Biometalfiber(BMF), of which its shrinkage by voltage application is mainly used, as exothermic material. This time we used it as an ablation material by its heat generation due to the shrinkage. We simultaneously succeeded in minimizing the size of the heater that can be inserted into even 5Fr catheter by using Biometalhelix(BMX), which is BMF processed into a spiral form and achieving the objective to minimize the invasion. The use of inexpensive commercial materials in this study has enabled treatment not only in Japan but also in developing countries.

Free Research Field

有機機能化学

Academic Significance and Societal Importance of the Research Achievements

本研究の特徴は、目的達成のためにＢＭＸ、導電性接着剤という新素材を活用した所にある。これらの材料は市販品であり安価である。国内での治療には勿論、開発途上国での治療にも適用可能であると考えら、国際貢献にも繋がるものである。
また、現在市販されていないが直径（φ）0.03㎜マグネシウム合金細線（Ｍｇ細線）の存在がある。これが市販されれば、マイクロヒーター（ＭＨ）の更なる極小化が期待できる。
本研究で作成・評価したＭＨは当初7フレンチを目標に敷いていたが最終的に5フレンチへの挿入を可能にした。