2021 Fiscal Year Final Research Report
Preliminaly study of L-FABP in obstructive nephropathy.
| Project/Area Number |
19K12838
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 90130:Medical systems-related
|
|---|
| Research Institution | Iwate University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
佐藤 洋 岩手大学, 農学部, 教授 (00726606)
宮崎 雅雄 岩手大学, 農学部, 教授 (20392144)
|
|---|
| Project Period (FY) |
2019-04-01 – 2022-03-31
|
| Keywords | L-FABP / 腎臓 / 水腎症 |
|---|
| Outline of Final Research Achievements |
The sensitivity of existing test methods is insufficient for the progress and prognosis evaluation of obstructive nephropathy, and the consensus treatment guidelines have not been clarified. The purpose of this study was to clarify the biochemical and histopathological relationship between the liver type fatty acid binding protein (L-FABP) and the progression/prognosis of obstructive nephropathy. In this study, it was suggested that L-FABP could predict the prognosis of renal function after relieving obstruction in cats. In addition, it was suggested that L-FABP in renal pelvic urine could be associated with histological changes in the obstructed kidney in rats.
|
| Free Research Field |
獣医外科学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究における最も独創的な点は、伴侶動物であるネコのCKDモデルを当該分野の研究に応用することである。本研究の目的は、ヒト の前臨床モデルとして、ネコ及びラットの閉塞性腎障害モデルを用いて病態進行とL-FABPとの関連性を生化学的および病理組織学的に明らかにし、L-FABPを用いた新たな治療戦略を提案することである。本研究から得られるデータは、ヒトの臨床研究では入手困難なL-FABPの必要不可欠な基礎データにもなり得ると考えられる。
|
