Development of a new drug-induced nephropathy risk prediction model by integrating medical and meteorological real world data

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K13914
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 08010:Sociology-related
• Research Institution: Kumamoto University
• Principal Investigator: Kondo Yuki 熊本大学, 大学院生命科学研究部(薬), 准教授 (90721879)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 急性腎障害 / 薬剤性腎障害 / 非ステロイド性抗炎症薬 / バラシクロビル / 季節性

Outline of Final Research Achievements

Drug-induced acute kidney injury is a frequent and severe adverse event. In this study, we examined the association of season and temperature on acute kidney injury, including drug-induced renal injury caused by nonsteroidal anti-inflammatory drugs (NSAIDs) and baracyclovir, and renal function. As a result, we found that NSAIDs and valacyclovir-related acute kidney injury may increase in the summer. We also examined the relationship between temperature and the number of cases of acute kidney injury, changes in glomerular filtration rate and seasons, we found the possibility that they are related.

Free Research Field

医療薬学

Academic Significance and Societal Importance of the Research Achievements

本研究は、本邦において薬剤性腎障害の原因薬剤としてよく報告されているバラシクロビルや非ステロイド性抗炎症薬（NSAIDs）を使用している患者における急性腎障害のリスクが季節により異なる可能性を示唆した研究である。
また、同一個人間でも季節によりベースラインの腎機能が変化する可能性も見出した。今後詳細な検討が必要ではあるが、本研究成果は薬剤性腎障害の対策を考える上で有用な基礎情報になると考えられる