Evaluation of an Oral Immunotherapy using peptide milk

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K14025
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 08030:Family and consumer sciences, and culture and living-related
• Research Institution: Kanagawa Children's Medical Center (Clinical Research Institute)
• Principal Investigator: INUO Chisato 地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 部長 (30586780)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 食物アレルギー

Outline of Final Research Achievements

Recent reports have described the usefulness of oral immunotherapy, which aims to cure food allergy by having the patients gradually consume the causative food. However, systemic allergic symptoms such as skin, gastrointestinal, and respiratory symptoms are frequently induced during treatment. We focused on the low allergenicity of peptide milk, in which milk components are partially hydrolyzed. The results suggest high level of safety in two types of peptide milk containing both casein and whey.

Free Research Field

アレルギー

Academic Significance and Societal Importance of the Research Achievements

一般的に乳児は完全母乳栄養で育てられる。しかし、完全な母乳育児が不可能な場合に粉ミルクを摂取することになる。初めて牛乳タンパクを摂取する際にアナフィラキシーを含むアレルギー症状を示す小児がいることから、これらの粉ミルクの安全性の評価が重要となる。さらに、そのような症状を呈する牛乳アレルギー乳児が、安全な粉ミルクを摂取しながら、アレルゲンの寛解を誘導できるような可能性をこの研究結果は示唆している。