Risk assessment of biogenic amines in baby foods

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K14027
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 08030:Family and consumer sciences, and culture and living-related
• Research Institution: Osaka Institute of Public Health
• Principal Investigator: Awazu Kaoru 地方独立行政法人 大阪健康安全基盤研究所, 衛生化学部, 主任研究員 (30435888)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 生理活性アミン / biogenic amines / ベビーフード / 健康影響評価 / HPLC-FL

Outline of Final Research Achievements

To evaluate the health effects of biogenic amines (BAs) contained in baby foods on infants, we developed a BAs analysis method using HPLC-FL measurement. We analyzed six BAs (Him, Tym, Phm, Tpm, Put, Cad) that have been recognized to have health effects on humans, two BAs (Spd, Spm) contained in fresh foods, and an internal standard (1,7-Diaminoheptane).
After purification using a WCX column, fluorescent derivatization with fluorescamine and HPLC-FL measurement were performed to establish an analytical method for seven BAs (Him, Tym, Spd, Spm, Put, Cad, Phm) and internal standard substances applicable to wet-type baby foods.

Free Research Field

食品分析

Academic Significance and Societal Importance of the Research Achievements

国内における食品のBAの含有実態に関する研究は、魚介類加工品および発酵食品などの微生物の増殖で生成されるBAを対象に実施されてきた。確立した分析法を用いて国内に流通するベビーフードのBAの含有実態を調査し、乳幼児への健康影響や製品の特徴と含有量の関連を明らかにすることで、健康被害の防止やベビーフードの品質改善に役立つと考える。