Effect of maternal diet-induced obesity on postnatal immunologic ageing

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K14036
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 08030:Family and consumer sciences, and culture and living-related
• Research Institution: Sagami Women's University
• Principal Investigator: Imai Atsuko 相模女子大学, 栄養科学部, 講師 (00580086)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 母子 / 高脂肪食 / 炎症 / DOHaD / 加齢

Outline of Final Research Achievements

This study examined the effect of diet induced obesity (DIO) on aging process in offspring. The body weights in offspring from dam exposed to a high -fat (HF) diet was significantly higher in the early stage of life but then became lower in the later stage of life. The expression of splenocyte heat shock protein 70 (HSP70), a factor that regulates inflammation-related cytokine production and modulates inflammatory pathophysiology, was significantly higher in response to endotoxin shock in offspring from dam exposed to a HF diet. In addition, a significant positive correlation was observed between the HSP70 expression and the IL-10 production by T cell mitogen stimulation. These results suggest that a maternal DIO may influence on inflammatory pathophysiology in offspring.

Free Research Field

臨床栄養学

Academic Significance and Societal Importance of the Research Achievements

「将来の健康や特定の病気へのかかりやすさは、胎生期や生後早期の環境を強く受けて決定される」というDOHaDの概念から、次世代の健康寿命の伸展や病気の予防のためには、胎生期や生後早期からの対策が必要である。しかしながら、母親の栄養環境が出生子に及ぼす影響の理解は不十分である。本研究では妊娠中の食餌誘導性肥満が出生仔マウスの炎症病態の調節機構に影響を及ぼす可能性を示した。動物モデルを用いた本研究の結果はすぐヒトに外挿できるものではないが、栄養状態と免疫機能の関わりを広く追及することは超高齢社会で増加する疾患の病態を理解し、栄養療法を発展させる上で必要不可欠である。