Development for a comprehensive intervention for depression in breast cancer patients and its verification of effectiveness

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K14452
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 10030:Clinical psychology-related
• Research Institution: Nagoya City University
• Principal Investigator: Toshishige Yuko 名古屋市立大学, 医薬学総合研究院(医学), 助教 (70813848)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 対人関係療法 / うつ病 / 遺族

Outline of Final Research Achievements

While conducting IPT for depression and complicated grief (persistent grief disorder) in bereaved families, an IPT manual adapted to Japanese culture was developed, using treatment strategies tailored to Japanese culture-specific practices and views of life and death. Using the manual, IPT was conducted with bereaved families, and case reports of IPT for bereavement-related depression and IPT for persistent grief disorder were published in English-language journals in FY2022 and FY2023, respectively. In FY2023, a pilot study of IPT for bereavement-related depression with comorbidities such as complicated grief (prolonged grief disorder) was published in an English journal, demonstrating the feasibility, safety and preliminary effectiveness of IPT adapted to Japanese culture.

Free Research Field

対人関係療法

Academic Significance and Societal Importance of the Research Achievements

乳がん患者のうつ病に限らず、遺族のうつ病・複雑性悲嘆（遷延性悲嘆症）にも対象を広げて、注力した。大切な人との死別は、人生における最も深刻なストレス因の1つであり、うつ病・複雑性悲嘆（遷延性悲嘆症）となる場合がある。これから多死社会を迎える日本において、日本の遺族のうつ病・複雑性悲嘆（遷延性悲嘆症）に対する心理療法の確立・普及は喫緊の課題と考えられた。本研究にて、日本文化に適用させたIPTマニュアルを開発し、日本文化に適用させたIPTの実施可能性、安全性および予備的有効性を示すことができたことで、無作為化対照試験等の研究につながる基盤を構築することができた。