2023 Fiscal Year Final Research Report
Identifying ARMS using Rorschach Test and Stress biomarkers in saliva
| Project/Area Number |
19K14455
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 10030:Clinical psychology-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | At Risk Mental State / ロールシャッハ・テスト / 唾液 / 統合失調症 |
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| Outline of Final Research Achievements |
At-Risk Mental State (ARMS) has been proposed as a prospective concept of the prodromal period of schizophrenia. A semi-structured interview is used to identify ARMS, but in order to improve its accuracy, we conducted an examination using the Rorschach test, which is a projective psychological test, and analyzed the components of saliva as a biochemical index. As a result, compared to schizophrenia, ARMS is considered to be characterized by being able to see things as a whole and exhibiting emotional hypersensitivity associated with interpersonal relationships. In addition, compared to healthy subjects, stress reactivity was higher, and biochemical indicators showed increased cortisol levels.
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| Free Research Field |
臨床心理学
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| Academic Significance and Societal Importance of the Research Achievements |
統合失調症の前駆段階としてAt Risk Mental Stateが提唱されている。本研究ではARMSの同定法として、臨床場面で広く使用されているロールシャッハ・テストに加え、唾液による生化学的手法を用いて、ARMSの特性を明らかにした。健常とARMS、ARMSと統合失調症の間には差異が存在し、ARMSでは健常と比較してストレス反応性が高く、統合失調症と比較した場合には認知機能の働きが良好である一方で、情動の敏感さが示された。これらの知見はARMSをより早期に同定できる可能性を含んでおり、ARMSの同定が正確かつ迅速に行われることで、統合失調症の発症予防に繋げ得るという点で社会的意義がある。
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