2020 Fiscal Year Final Research Report
A novel method for evaluation of column efficiency considering randomness of the intenral structure of columns
| Project/Area Number |
19K15420
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 28050:Nano/micro-systems-related
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| Research Institution | Kyushu University (2020)
Kyoto University (2019) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | マイクロ流体 / 分析化学 / クロマトグラフィー |
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| Outline of Final Research Achievements |
The efficiency of a chromatography column depends on the homogeneity of column packings and packed condition. The heterogeneity was controlled by microfabrication to evaluate the effect of heterogeneity of column packings and packed condition in this study. The microfabricated columns showed that the size difference between neighboring particles is a major factor of the column performance degradation in comparison with the void structure in the column and the size distribution of column packings.
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| Free Research Field |
マイクロ分析
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で作製したモデルカラムはカラム内均一性の指標として用いることで，従来，評価不能であった粒子充填カラム内部の構造の不均一性，充填状態に関する情報が得られるようになる。カラム効率の向上は根本的な分析性能の向上につながる。近年は3Dプリンタなどの発展により，一体成形型のカラムの期待も高まっており，カラム内充填構造がカラム性能に与える影響評価する本手法が与えるカラム設計に与える学術的意義は大きい。
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