Intracellular synthesis of anti-cancer agent by ligand delivery cheimstry

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K15690
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 37010:Bio-related chemistry
• Research Institution: Tohoku University
• Principal Investigator: Koseki Yoshitaka 東北大学, 多元物質科学研究所, 助教 (80780634)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 有機合成 / ドラッグデリバリーシステム

Outline of Final Research Achievements

This study aimed to synthesize the SN-38, an anticancer agent, in cancer cells for anticancer therapy without side effects. The results of this study were summarized as follows: 1) A new synthesis method has been established that can synthesize SN-38 in a shorter process than the existing synthesis method. 2) It was found that the skeleton formation reaction proceeds with a palladium catalyst by using the partial structure of SN-38.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、がん治療に使用されているSN-38を既存の手法よりもの簡便に合成する新規合成法の開発した。本手法を応用することで、将来的により安価にがん治療を受けることができるようになることが期待される。