2021 Fiscal Year Final Research Report
Microbial production of rare fatty acid curing atopic dermatitis by normalizing skin bacterial flora
| Project/Area Number |
19K15729
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 38020:Applied microbiology-related
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ビフィズス菌 / C16モノエン酸 / アトピー性皮膚炎 / 黄色ブドウ球菌 / 表皮ブドウ球菌 |
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| Outline of Final Research Achievements |
With the aim of developing and producing a selective antibacterial agent for Staphylococcus aureus that causes atopic dermatitis, we surveyed for microorganisms that produce rare fatty acids and attempted to improve their productivity. So far, various evaluations have been carried out, such as searching for producing microorganisms, selecting high-producing strains, setting high-producing culture conditions, discovering useful additives, and further improving the production method by aerating carbon dioxide gas. As a research result, we found the production of a rare fatty acid 16: 1Δ7, which has antibacterial properties against bifidobacteria. In addition, the effectiveness of L-cysteine and carbon dioxide was shown not only in the growth of bifidobacteria but also in the production of fatty acids. In addition, a high-production mutant strain was obtained by introducing a chemical mutation.
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| Free Research Field |
応用微生物学
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| Academic Significance and Societal Importance of the Research Achievements |
ビフィズス菌において、脂質・脂肪酸に関する研究例はほとんどないため、基礎学術的意義の高い研究成果である。一方で、ヨーグルトなど食品として利用され、健康効果についても良く知られるビフィズス菌において抗菌性脂肪酸の蓄積を見出したことは、将来的な抗菌性脂肪酸の実用化や社会実装に向けた研究開発の第一歩となるものと期待される。
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