Exploration of the mechanism for cellular toxicity by trans fatty acid that is different from natural fatty acids

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K15775
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Teikyo University
• Principal Investigator: Ishibashi Kenichi 帝京大学, 薬学部, 助教 (00707458)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: トランス脂肪酸 / インスリン応答性 / Akt / 膜リン脂質

Outline of Final Research Achievements

Excessive intake of industrial produced trans fatty acids (TFAs) induces cellular toxicity. Our previous studies indicate that the mechanism for TFAs-induced cellular toxicity is different from that for saturated fatty acid-induced cellular toxicity. However, detail mechanism for TFAs-induced cellular toxicity is not elucidated. We revealed that persistent exposure to elaidate, a TFA, results in production of elaidate-conjugated phospholipids and alteration in composition of phospholipid species. Moreover, alteration in composition of phospholipid species is involved in an impairment of accumulation of Akt at the plasma membrane. We further found the candidate gene which is involved in elaidate-induced alteration in composition of phospholipid species. Thus, our study indicated a mechanism for TFAs-induced cellular toxicity.

Free Research Field

食品化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、トランス脂肪酸が引き起こす細胞機能障害に関わる分子をいくつか明らかにした。これらの分子の量や活性を指標とすれば、トランス脂肪酸による細胞機能障害の把握や予測が可能になると考える。これによりトランス脂肪酸の摂取量と疾患発症との関係をより正しく評価できる可能性があり、疾患発症との新たな関係の解明や摂取量の提言に貢献できると考える。