To evaluate the regulatory effects of collagen-derived peptides on osteoblast differentiation

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K15794
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Josai University
• Principal Investigator: Kimira Yoshifumi 城西大学, 薬学部, 助教 (00635443)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: コラーゲンペプチド / 骨芽細胞

Outline of Final Research Achievements

Skeletal disorders are associated with an increase in individuals requiring caregiving and a reduction in healthy life expectancy, highlighting the need for prevention. Collagen peptides have been reported to be effective in preventing skeletal disorders, but their mechanism of action remains unclear. Therefore, we focused on the interaction between collagen peptides and Fox family transcription factors, which are involved in the function of osteoblasts, to elucidate the mechanism underlying the promotion of osteoblast differentiation. We found that the Pro-Hyp component of collagen peptides interacts with Foxg1, Foxo1, and Runx2 proteins, inducing the transcription of Runx2, the master transcription factor for osteoblast differentiation. Based on these findings, collagen peptides are believed to promote osteoblast differentiation through interaction with nuclear transcription factors, ultimately enhancing bone formation.

Free Research Field

食品機能学

Academic Significance and Societal Importance of the Research Achievements

本研究課題では、コラーゲンペプチドが骨芽細胞の分化を調節するための共通のキーとなる分子を特定し、その骨格系における作用メカニズムを解明することを目標とした。本研究により、コラーゲンペプチドの一つPro-Hypが結合し、相互作用する分子を特定できた。食品として摂取される生理活性ペプチドが転写因子と相互作用して骨芽細胞の分化を亢進し骨形成を調節することが理解されることで、機能性食品摂取が骨格系疾患の改善や予防に寄与する可能性が広がり、社会的に重要な意味を持つと考えられる。