Effects of vasopressors on cardiovascular function in dogs with mitral valve insufficiency.

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K15997
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 42020:Veterinary medical science-related
• Research Institution: Nihon University (2020-2023); Tokyo University of Agriculture and Technology (2019)
• Principal Investigator: GOYA Seijirow 日本大学, 生物資源科学部, 助教 (20836887)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 犬 / 僧帽弁閉鎖不全症 / 昇圧薬 / 低血圧

Outline of Final Research Achievements

This study revealed that atropine premedication before administering vasopressors to dogs with hypotension during anesthesia prevents reflex bradycardia and obtain a more effective blood pressure increasing effect.
Phenylephrine, which only has a vasoconstrictor effect, was able to obtain a sufficient blood pressure increasing effect at high doses, but it also potentially increasing the risk of congestive heart failure due to increased left ventricular preload. On the other hand, continuous intravenous administration of noradrenaline showed sufficient blood pressure increasing effect without excessively increasing left ventricular preload. We concluded that continuous intravenous administration of noradrenaline is the most effective procedure for hypotensive dogs with mitral valve regurgitation.

Free Research Field

循環器内科

Academic Significance and Societal Importance of the Research Achievements

低血圧は麻酔時に最も頻発する合併症であり、治療には昇圧薬が用いられる。僧帽弁閉鎖不全症は犬でよく認められる心疾患であるが僧帽弁閉鎖不全症の犬の麻酔時低血圧に対する適切な昇圧薬に関してよくわかっておらず、麻酔自体が忌避される理由の1つとなっていた。本研究成果は僧帽弁閉鎖不全症の犬の安全な麻酔管理に貢献した。また犬という動物種において昇圧薬誘発性の心拍数低下がよく認められることを明らかにしたことは、犬が迷走神経主体の動物である可能性を提示した点で学術的価値がある。