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2022 Fiscal Year Final Research Report

Unveiling vulnerability of the neural connectivity controlling nicotine intake in marmoset brain development

Research Project

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Project/Area Number 19K16031
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 42040:Laboratory animal science-related
Research InstitutionCentral Institute for Experimental Animals

Principal Investigator

Seki Fumiko  公益財団法人実験動物中央研究所, ライブイメージングセンター, 主任 (40771407)

Project Period (FY) 2019-04-01 – 2023-03-31
Keywordsマーモセット / MRI / 脳活動 / 発達 / 手綱核
Outline of Final Research Achievements

The project aimed to establish the method for evaluating brain activity associated with habenular nucleus - interpeduncular nucleus connection using MRI and cognitive assessment. If neural activity of habenular - interpeduncular nucleus connectivity is restrained by use of chemogenetic technology, its activity would be similar to the neural activity when we take nicotine.
The high resolution and high contrast MRI were acquired to visualize the connectivity between habenular nucleus and interpeduncular nucleus. Also, functional MRI was optimized to evaluate the activation at the whole brain level. In addition, longitudinal MRI was conducted to identify when the volume change due to development lasted. It was found that the volume decrease was continued after the age of 24 months, the timepoint of adulthood. Such base data would contribute to evaluate the brain activity changed associated with brain development or intervention.

Free Research Field

実験動物学

Academic Significance and Societal Importance of the Research Achievements

非ヒト霊長類である実験動物のマーモセットは、他霊長類と比べ発達期間が短くヒトの脳発達を理解する上で適したモデルの一つである。マーモセットとヒトと共通したMRIをモダリティとして使用出来ればスムースな比較研究が可能となる。本研究ではマーモセットの脳発達を多面的に評価するための基盤を確立した。マーモセットの発達に伴う脳形態の変化はヒトと同様性成熟に達する年齢より長く変化することを見出した。また覚醒下における全脳活動を評価する方法を確立した。これらから子どもがより脆弱とされているニコチン依存について、脳発達の度合いがもたらす影響について評価するデータを整えた。

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Published: 2024-01-30  

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