The analysis of the transposon repression performed by germline-specific KRAB-ZFP

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K16035
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 43010:Molecular biology-related
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Yashiro Ryu 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 ラジオアイソトープ管理室, リサーチフェロー (70838119)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: DMD / MLKL / 細胞死 / アポトーシス / ネクロトーシス

Outline of Final Research Achievements

Duchenne Muscular Dystrophy (DMD) is the innate disease that is difficult to treat completely. Nowadays, a new treatment method is developed, however even though the method is correct theoretically, some patients can have no effectivity. Then in this research, a basic research of DMD which is focused in cell death system was performed and I tried to discover a new strategic way for DMD treatment. In this research, I could unveil the cell death system of DMD muscle cells was higher level than that of wild type muscle cells and this was caused by two major cell death pathways, Apoptosis and Necroptosis.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

デュシェンヌ型筋ジストロフィー(DMD)は生まれつきの難治性疾患であり、難病であるがゆえ、治療法開発が進まなかった。近年開発された治療法についても、理論的には正しくても効果のない人も大勢いる。本研究では、細胞普遍的な経路である細胞死に着目し、DMDでは通常の筋肉細胞よりもより激しく細胞死が起こることを示唆する結果を得た。報告の少ない細胞死とDMDの関係性を生化学的に検証した本研究は、将来の細胞死に着目したDMD治療薬研究の参考になる可能性が期待される。