2022 Fiscal Year Final Research Report
Elucidation of membrane expansion mechanism in autophagosome formation
| Project/Area Number |
19K16071
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 43030:Functional biochemistry-related
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Kotani Tetsuya 東京工業大学, 生命理工学院, 特任助教 (10724643)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | オートファジー / 酵母 |
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| Outline of Final Research Achievements |
Atg2, which is essential for autophagosome formation, has lipid transfer activity and is thought to supply lipids from the endoplasmic reticulum to the autophagosomal membrane. Atg2 does not always bind to the endoplasmic reticulum, suggesting that it becomes capable of interacting with it only during autophagosome formation. However, the regulatory mechanism of the interaction between Atg2 and the endoplasmic reticulum remains poorly understood. In this study, we obtained results suggesting that Atg2 is phosphorylated during autophagosome formation, which facilitates its interaction with the endoplasmic reticulum.
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| Free Research Field |
分子細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
これまでにオートファゴソーム形成に必須のタンパク質の個々の機能は明らかとなりつつある。しかし、それらの機能がどのようにして制御されているのか、また、これらタンパク質群がどのように協調的に働いているかなど、まだ多くの疑問が残されており、オートファゴソーム形成の完全なる理解には至っていない。本研究ではオートファゴソーム形成に必須のAtg2の機能制御機構に関する知見を得た。本研究での結果を基に研究を進めることで、オートファゴソーム形成機構のさらなる理解につながると期待できる。
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