Functional analysis of O-GlcNAc glycan to determine the properties of EGFR ligands

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K16073
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 43030:Functional biochemistry-related
• Research Institution: Nagoya University
• Principal Investigator: Ogawa Mitsutaka 名古屋大学, 医学系研究科, 助教 (70727429)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 糖鎖 / EGFR

Outline of Final Research Achievements

This is the first study in the world to demonstrate that O-GlcNAc glycan may be a glycan that regulates not only Notch signaling but also EGFR signaling. If the diversity of O-GlcNAc glycan found in this study can be demonstrated to regulate EGFR signaling, it will lead to a new understanding of the biological significance of O-GlcNAc glycan.

Free Research Field

糖鎖生物学

Academic Significance and Societal Importance of the Research Achievements

本研究では、癌の悪性化や個体発生に重要な機能をもつEGFRシグナルを制御する新しい糖鎖修飾を見出すことができた。このことは、癌の成り立ちや生物の成り立ちを理解する上で、非常に重要な発見であり、創薬研究への応用や再生医療分野への貢献が期待でき、学術的にも社会的にも非常に意義がある研究成果である。