2022 Fiscal Year Final Research Report
Formation and function of ellipsoids in organogenesis
Project/Area Number |
19K16144
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 44020:Developmental biology-related
|
Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
Akiyama Ryutaro 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 (00790403)
|
Project Period (FY) |
2019-04-01 – 2023-03-31
|
Keywords | 器官形成 / 楕円体 |
Outline of Final Research Achievements |
This study aimed to quantitatively analyze and understand the ellipsoid formation and function of the organ, and to clarify the interaction between three-dimensional structure and function in organogenesis employing the Kupffer's vesicle (KV) as a model organ. In this study, we established a transgenic line to analyze the 3D structure of KV. Furthermore, our data suggested that the signal activated by mechanical stimuli is involved in the construction of the ellipsoid structure of KV.
|
Free Research Field |
発生生物学
|
Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は、動物が器官のかたちをどのように作り上げるのか、その仕組みを考える上で重要な知見と成り得る。また、本研究による器官の三次元形態の制御機構に関する理解は、再生医療に必須な「器官のかたちを自由に操る技術」などの応用面への展開が期待される。
|